Zn thiosacharinates: From ionic to polymeric structures. Synthesis, characterization and cell proliferation inhibition studies

摘要

A series of Zn thiosacharinates complexes with nitrogen donor co-ligands were synthesized: [Zn(tsac)(2) (o-phen)], [Zn(tsac)(2)(TMDP)](n), [(4,4'-bipy)H-2][Zn(tsac)(4)] ]Zn(tsac)(2)(2,2'-bipy)], ]Zn(tsac)(2)(2,2'-bquin)], (tsac, thiosaccharinate anion: l,l-dioxo-l,2-benzisothiazole-3-thiolato, C7H4NO2S2, o-phen: 1,10'phenantrohne, TMDP: trimethylenedipyridine, 2,2'-bipy: 2,2'-bipyridine, 4,4'-bipy: 4,4'-bipyridine, 2,2'bquin: 2,2'-biquinolme). They were fully characterized by means of FTIR, C-13 and H-1 NMR, elemental analysis and conductivity measurements. Three of them, [Zn(tsac)(2)(o-phen)], ](4,4'-bipy)H-2][Zn(tsac)(4)], [Zn(tsac)(2)(TMDP)](n) were also characterized by X-ray single crystal diffractometry and their crystal structures are described herein. DFT geometry optimization for the [Zn(tsac)(2)(o-phen)] complex was performed and its vibrational spectra was predicted. Moreover, we studied the effects of the five complexes on cell proliferation, thus providing preliminary evidence for their therapeutic potential as anti-cancer drugs. (C) 2018 Elsevier B.V. All rights reserved.