Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

Carter Rachel J.; Nickson Catherine M.; Thompson James M.; Kacperek Andrzej; Hill Mark A.; Parsons Jason L.

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Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

机译：高线性能量转移α-颗粒和质子诱导的复杂DNA损伤触发特定的细胞DNA损伤反应

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Purpose: To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin.

机译：目的：研究识别和处理电离辐射（IR）诱导的复合DNA损伤（CDD）的精确机制，其中两个或更多个DNA病变紧邻，其在蜂窝DNA中，其与组蛋白形成染色质。

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《International Journal of Radiation Oncology, Biology, Physics》 |2018年第3期|共9页
作者
Carter Rachel J.; Nickson Catherine M.; Thompson James M.; Kacperek Andrzej; Hill Mark A.; Parsons Jason L.;
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作者单位

Univ Liverpool Dept Mol &

Clin Canc Med Canc Res Ctr 200 London Rd Liverpool L3 9TA Merseyside;

Univ Liverpool Dept Mol &

Clin Canc Med Canc Res Ctr 200 London Rd Liverpool L3 9TA Merseyside;

Univ Oxford Oxford Inst Radiat Oncol MRC Gray Labs Canc Res UK Oxford England;

Clatterbridge Canc Ctr NHS Fdn Trust Natl Eye Proton Therapy Ctr Bebington England;

Univ Oxford Oxford Inst Radiat Oncol MRC Gray Labs Canc Res UK Oxford England;

Univ Liverpool Dept Mol &

Clin Canc Med Canc Res Ctr 200 London Rd Liverpool L3 9TA Merseyside;

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正文语种 eng
中图分类放射医学;
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1. Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response [J] . Carter Rachel J., Nickson Catherine M., Thompson James M., International Journal of Radiation Oncology, Biology, Physics . 2018,第3期

机译：高线性能量转移α-颗粒和质子诱导的复杂DNA损伤触发特定的细胞DNA损伤反应
2. A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: Identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci [J] . Mok MTS, Henderson BR Cellular Signalling . 2010,第1期

机译：BRCA1核定位与14种DNA损伤反应蛋白和结构域的比较：鉴定DNA损伤诱导灶上BRCA1和53BP1之间的特异性差异
3. Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner [J] . A Rockstroh, A Kleinert, M Kramer, Oncogene . 2007,第1期

机译：细胞应激以p53受控的方式独立于DNA损伤而触发人类拓扑异构酶I损伤反应
4. Absolute measurement of low energy electron-induced strand-break damage in films of plasmid DNA and plasmid DNA/Dap~(2+) complexes [C] . O. Boulanouar, M. Rezaee, M. Fromm, ICPEAC . 2014

机译：质粒DNA和质粒DNA / DAP薄膜中低能电子诱导的股线损伤的绝对测量和质粒DNA / dap〜（2+）配合物中的低能量
5. The DNA damage induced by, and cellular responses to, the C-1027 family of antitumor antibiotic radiomimetic enediynes. [D] . Kennedy, Daniel R. 2007

机译：由C-1027抗肿瘤抗生素放射模拟烯二炔家族诱导的DNA损伤和细胞应答。
6. Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response [O] . Rachel J. Carter, Catherine M. Nickson, James M. Thompson, -1

机译：高线性能量转移α-粒子和质子引起的复杂DNA损伤触发特定的细胞DNA损伤反应
7. Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET) [O] . Nikitaki, Zacharenia, Nikolov, Vladimir, Mavragani, Ifigeneia V., 2016

机译：暴露于变化的线性能量转移（LET）的电离辐射后，对人体细胞系统中复杂的DNA损伤诱导和修复的测量

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

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