Combinations of colistin solutions and nebulisers for lung infection management in cystic fibrosis patients

摘要

In this work different nebulisers were investigated in order to assess their efficiency in combination with colistimethate sodium (CMS) inhalation products. Four nebulisers, namely I-neb (R), Aeroneb (R) Go, eFlow (R) rapid and PARI LC (R) Sprint were studied in terms of delivered dose (DD), drug delivery rate (DDR) and respirable dose (RD) of CMS. The goal was to provide scientific data to physicians for prescribing the most appropriate nebuliser for the CMS specific user.