Di-μ-oxidovanadium(V) Complex with N'-[(Z)-Phenyl(pyridin-2-yl)methylidene]pyridine-4-carbohydrazide: Synthesis, Structural Characterization and in vitro Antidiabetic Inhibition Study

摘要

Schiff base and its one di-μ-oxidovanadium(V) complex have been synthesized by the reaction of vanadyl sulphate pentahydrate and N'-[(Z)-phenyl(pyridin-2-yl)methylidene]pyridine-4-carbohydrazide (HL). The HL and its complex [(L)VO(μ-O)2VO(L)] have been characterized by micro-analysis, UV-visible and electrochemical techniques. The ligand and its complex have also been characterized by single crystal X-ray technique. The ligand crystallizes in triclinic crystal system with P1 space group while, complex crystallizes in monoclinic crystal system with P21/c space group. The electronic spectrum is as expected for vanadium(V) in an octahedral environment in each vanadium centers. The electronic structures of the ligand and the complex have been explained by density functional theory (DFT) calculations. In addition, in vitro insulin mimetic activity of the complex has also been evaluated.