Sulfadiazine Guanidyl Derivatives: Synthesis, Characterization and Docking Studies for Potential Antituberculosis Agents

摘要

Due to the wide range of pharmacological and biological activities, guanidine considered as one of the attractive pharmacophores. The presence of -CN3 group in guanidine compounds makes them to have efficient affinity towards various substituents with wide range of biochemical activities. In the present study, novel sulfadiazine guanidyl derivatives were synthesized and characterized by FT-IR, LC-MS and NMR spectral studies. The synthesized compounds were screened for antituberculosis activity and molecular docking study with InhA proteins was carried out. It was found that the compounds with electron donating groups exhibited superior activity.