Highly Effective Opening of Epoxides with Aromatic Amines in Presence of P-Cyclodextrin in Water

摘要

This paper reports a simple, mild, and convenient method to synthesize (3-amino alcohols. These β-Vamino alcohols were achieved in excellent yields (80-96 %) by ring-opening reaction of oxiranes with aromatic amines catalyzed by β-cyclodextrin at 30 °C in water. β-cyclodextrin as the catalyst greatly accelerated the reactions and can be recovered and reused.