Biological Screening Studies of DNA Relate Metal Complexes from Benzylidene-4-imino-2,3-dimethyl-l-phenyl-3-pyrazolin-5-one and 2-aminothiazole

摘要

Novel terdentate cationic complexes of Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) ion have been prepared using a Schiff base derived from benzylidene-4-imino-2,3-dimethyl-l-phenyl-3-pyrazolin-5-one and 2-aminothiazole. The structural features of metal-chelates have been confirmed by micro-analytical data, FAB-Mass spectra, powder XRD, SEM, FTIR, UV-visible, 'H NMR, EPR, CV and thermal analysis techniques. The analytical data of the complexes correspond well with the general formula [ML2]Cl2. The high conductance data of metal chelates supports their 1:2 electrolytic nature. The magnetic susceptibility and electronic absorption spectra of the complexes indicate that all the metal-chelates exhibit octahedral geometry around the central metal ion. Powder XRD data and SEM images persist that the complexes are nano size grain with polycrystalline structure. DNA interaction studies of [CuL]Cl2 complex have been done by electronic spectral and cyclic voltammetric measurements which revealed that the binding occurs through intercalation between complex and DNA interaction of [CUL2]Cl2 complex with CT-DNA leads to hypochromism. The MIC values against the growth of microorganisms are lower for metal chelates than the ligand. This is mainly due to lipophilicity of metal ion in complexes.