A New Series of Moisture Stable Metallacyclic Heteroleptic Titanium(IV)Complexes of 8-Hydroxyquinoline: Synthesis,Characterization,Stability Study and Cytotoxicity Evaluation

摘要

A new series of moisture resistant metallacyclic titanium(IV)derivatives prepared from 8-hydroxyquinoline of the general formulae [(Q2)Ti {(Li)(L2OR))](3a-b,3d-e),[(Q2)Ti{(L,)(L3)} ](3c and 3f)and [(Q2)Ti(L4)](3g and 3h)is synthesized by interacting the precursor molecule [(Q2)Ti(OiPr)2](2)with various 2-heteroaryl methyl ketone oximes and various alkoxyalkanols/2-hydroxypyridine or only with catechol/resorcinol in 1:1:1 or in 1:1 molar ratios in anhydrous boiling toluene(where,HQ = 8-hydroxyquinoline;iPr = isopropyl;L1H = HONC(Me)py-2/HONC(Me)fu-2;L2 = O-CH2-CH2-;R = CH3,C2H5;L3H = 2-hydroxypyridine and L4H = catechol/resorcinol).Stabihty study revealed that these molecules were stable for a period of 72 h.Mononuclear nature of the complexes was confirmed through mass spectral analysis.Thermogravimetric results explain the multistage fragmentation of the complexes at 900 °C.NMR,FTIR,and UV-visible spectral data suggested that titanium-ligands attachment is in a hexa-coordinated manner.Additionally,all these molecules were tested for their tumour inhibiting potential against MDA-MB-231 human breast carcinoma cell line.