Technology evaluation: ISIS-104838, OraSense.

Kennewell P

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Technology evaluation: ISIS-104838, OraSense.

机译：技术评估：ISIS-104838，OraSense。

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OraSense Ltd (a joint venture between Isis Pharmaceuticals Inc and Elan Corp) is developing ISIS-104838, an antisense oligonucleotide specific for TNF alpha mRNA, as an inhibitor of TNF alpha synthesis. The compound is being developed for the potential treatment of inflammatory diseases such as rheumatoid arthritis, Crohn's disease and psoriasis. This antisense oligonucleotide is currently undergoing phase II clinical trials for RA and Crohn's disease.

机译：OraSense Ltd（Isis Pharmaceuticals Inc和Elan Corp之间的合资企业）正在开发ISIS-104838，这是一种针对TNFαmRNA的反义寡核苷酸，可作为TNFα合成的抑制剂。该化合物正在开发中，可用于治疗炎症性疾病，例如类风湿性关节炎，克罗恩病和牛皮癣。该反义寡核苷酸目前正在针对RA和克罗恩氏病进行II期临床试验。

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《Current Opinion in Molecular Therapeutics》 |2003年第1期|共5页
作者
Kennewell P;
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正文语种 eng
中图分类治疗学;
关键词
Anti-Inflammatory Agents; Arthritis; Rheumatoid; Crohn Disease; Immunosuppressive Agents; 消炎药; 关节炎; 类风湿; Crohn病; 免疫抑制剂; 寡核苷酸类; 反义; 肿瘤坏死因子;

机译：Anti-Inflammatory Agents;Arthritis;Rheumatoid;Crohn Disease;Immunosuppressive Agents;消炎药;关节炎;类风湿;Crohn病;免疫抑制剂;寡核苷酸类;反义;肿瘤坏死因子;

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Technology evaluation: ISIS-104838, OraSense.

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