Candida rugosa lipase catalysed preparation of L-prolyl,L-phenylalanyl,L-tryptophanyl and L-histidyl esters of carbohydrates

摘要

L-Amino acyl(1-4)esters of carbohydrates(5-15)were synthesized through Candida rugosa lipase catalysis in non-polar solvent with yields in the range of 7-79%.In a reaction,involving unprotected and unactivated L-amino acids and carbohydrates,both monoesters(1-O-,2-O-,3-O-,4-O-,5-O-,6-O-and 6'-O-)and diesters(1,6-di-O,2,5-di-O-,2,6-di-O-,3,6-di-O-,4,6-di-O-and 6,6'-di-O-)were found to be formed in different proportions depending on the L-amino acids and carbohydrates employed.Among 80 individual esters synthesized by this procedure,67 are being reported for the first time.