Genes involved in senescence and immortalization

摘要

Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free redical toxicity. The role of telomere maintenance in immortalization and the roles of p16~(INK4A), p19~(ARF), p53 and other genes in senescence are bing further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.