New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/Oxovanadium(IV) Complex

摘要

Over the last two decades, we have proposed several types of orally active insulin-mimetic mononuclear zinc(II) complexes based on several coordination environments. Herein, we demonstrate the hypoglycemic activity and potentially low testicular toxicity of a binuclear Zn~(2+)/VO~(2+) complex of N,N'-bis(salicylidene)ethylenediamine ([(VOZn)fsaen]). The chemical structure of this complex was evaluated using an extended X-ray absorption fine structure (EXAFS) technique. The in vivo hypoglycemic effect of [(VOZn)fsaen] was evaluated using type-2-like diabetic model mice treated by daily oral administrations. The hetero-binuclear complex [(VOZn)fsaen] exhibited glucose-lowering effect without triggering morphological changes in the testes, despite the recognized potentially significant toxicity of oxovanadium(IV) (VO~(2+)) complexes in the testes.