Di- and tri-organotin(IV) complexes derived from aryltelluronic acids: Synthesis, structural characterization and in vitro cytotoxicities

摘要

Reactions of R2SnCl2 (R = Me) or R3SnCI (R = Me, Ph) with the respective dinuclear aryltellurinic acid (H6L1 = [3,4-Me2C6H3TeO(OH)(3)](2) and H6L2 = [3,5-Me(2)C(6)H(3)TeoOOH)(3)](2)) afforded two types of aryltelluronic organotin esters: [R2Sn(CH3OH)(R2SnCl)121, (L-1 = [3,4-Me2C6H3TeO4](2), R = Me: 1; L-2 = [3,5Me(2)C(6)H(3)TeO(4)](2), R = Me: 4) and [(R3Sn)(2)F-1]21, (L-1 = [3,4-Me2C6H3TeO4](2), R = Me: 2, R = Ph: 3; L-2 = [3,5-Me2C6H3TeIO4](2), R = Me: 5, R = Ph: 6). All the complexes were characterized by means of, 13C, elemental analysis, FT-IR, and NMR (1H 119Sn) spectroscopy as well as X-ray crystallography. Single crystal X-ray diffraction shows that they are isostructural and crystallized as Sn4Te2 molecules, in which an almost planar four-membered Te-2(mu(2)-O)(2) units are situated in the center. Moreover, what is novel about 1 and 4 is that there exists a centrosymmetric 8 -member macrocyle containing Sn2Te2O4 dipping perpendiculared to the Te2O2 ring. The geometry of the tellurium atom is described as a distorted octahedron, and tin atoms are best described as distorted tetrahedron and distorted trigonal bipyramid. Through intermolecular weak interactions, both complexes 1 and 4 have two dimensional network structures and complex 2 shows one dimensional infinite polymeric chain structure. Furthermore, in vitro cytotoxicities of complexes 1-6 were also evaluated, using human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). (C) 2016 Elsevier B.V. All rights reserved.