Ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages

摘要

A variety of functionalized furans were synthesized by way of a ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages. The feature of the reaction was facilitative preparation of furan derivatives good functional group tolerance. All reactions gave the desired products in moderate to good yields (56-89%) in the presences of [RuCl_2(p-cymene)] and K_2CO_3 in NMP at 120 °C.