Microwave Irradiation As a Substitute for Phase Transfer Catalyst in C- Alkylation Reactions

摘要

In this minireview, the possible utilization of the microwave (MW) technique in solid-liquid (S-L) phase C-alkylations is summarized. In the S-L phase C-alkylation of a series of simple active methylene containing compounds, such as diethyl malonate,ethyl acetoacetate and ethyl cyanoacetate, as well as P=O-containing derivatives, such as tetraethyl methylenebisphosphonate, diethyl cyanomethylphosphonate and diethyl ethoxycarbonylmethylphosphonate, in most of the cases, there is no need to use a phase transfer catalyst, as MW promotes the reaction in itself. Most of the C- alkylations was performed under solvent-free conditions. The elimination of the catalyst and solvent from the system means an environmentally friendly ("green")accomplishment.