PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

Syeda Fahima; Holmes Andrew P.; Yu Ting Y.; Tull Samantha; Kuhlmann Stefan Michael; Pavlovic Davor; Betney Daniel; Riley Genna; Kucera Jan P.; Jousset Florian; de Groot Joris R.; Rohr Stephan; Brown Nigel A.; Fabritz Larissa; Kirchhof Paulus

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PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

机译：PITX2调节心房膜电位和钠通道阻滞剂的抗心律失常作用

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BACKGROUND Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness are not known. Recent data suggested that paired like homeodomain-2 transcription factor (PITX2) might play an important role in regulating gene expression and electrical function of the adult left atrium (LA).

机译：背景技术抗心律失常药物被广泛用于治疗房颤（AF）患者，但是传达其可变有效性的机制尚不清楚。最近的数据表明，成对的同源域2转录因子（PITX2）可能在调节成人左心房（LA）的基因表达和电功能中起重要作用。

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《Journal of the American College of Cardiology》 |2016年第17期|共14页
作者
Syeda Fahima; Holmes Andrew P.; Yu Ting Y.; Tull Samantha; Kuhlmann Stefan Michael; Pavlovic Davor; Betney Daniel; Riley Genna; Kucera Jan P.; Jousset Florian; de Groot Joris R.; Rohr Stephan; Brown Nigel A.; Fabritz Larissa; Kirchhof Paulus;
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正文语种 eng
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antiarrhythmic drugs; atrial fibrillation; drug targets; electrophysiology; personalized medicine; rhythm control;

机译：抗心律失常药;房颤;药物靶标;电生理学;个性化药物;节律控制;

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1. PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers [J] . Syeda Fahima, Holmes Andrew P., Yu Ting Y., Journal of the American College of Cardiology . 2016,第17期

机译：PITX2调节心房膜电位和钠通道阻滞剂的抗心律失常作用
2. Atrial-selective K + channel blockers: potential antiarrhythmic drugs in atrial fibrillation? [J] . Ursula Ravens Canadian Journal of Physiology and Pharmacology . 2017,第11期

机译：心房选择性K +通道阻滞剂：心房颤动的潜在抗心律失常药物？
3. Atrial-selective K + channel blockers: potential antiarrhythmic drugs in atrial fibrillation? [J] . Ursula Ravens Canadian Journal of Physiology and Pharmacology . 2017,第11期

机译：心房选择性K +通道阻滞剂：心房颤动的潜在抗心律失常药物？
4. PITX2 Overexpression Leads to Atrial Electrical Remodeling Linked to Atrial Fibrillation [C] . Jieyun Bai, Yaosheng Lu, Andy C Y Lo, Computing in Cardiology Conference . 2019

机译：PITX2过表达导致与房颤相关的心房电重构
5. Cardiac ablation as the initial therapy for symptomatic atrial fibrillation results in less recurrance of atrial fibrillation when compared to antiarrhythmic therapy [D] . Mikhli, Erica 2011

机译：与抗心律失常治疗相比，心脏消融作为症状性心房颤动的初始治疗导致心房颤动的较少复发
6. PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers [O] . Fahima Syeda, Andrew P. Holmes, Ting Y. Yu, -1

机译：PITX2调节心房膜电位和钠通道阻滞剂的抗心律失常作用
7. PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers [O] . Syeda, Fahima, Holmes, Andrew P., Yu, Ting Y., 2016

机译：PITX2调节心房膜电位和钠通道阻滞剂的抗心律失常作用

PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

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