Hepatitis C and HIV Coinfection

摘要

Coinfection with hepatitis C virus (HCV) and HIV is common. Studies conducted prior to the advent of highly active antiretroviral therapy reported increased HCV liver disease severity in coinfected persons compared with those infected with HCV alone. In the current era, the influences of HIV and highly active antiretroviral therapy on the natural history of HCV liver disease are less well defined. Peginterferon alfa and ribavirin are the current standard of care in treating HCV, but HIV coinfection is-associated with lower response rates to treatment. Further research is needed to enhance our understanding of the natural history and pathogenesis of HCV liver disease in the setting of HIV coinfection and to identify more effective HCV treatments.