The oligodendrocyte- specific antibody 'CC1' binds Quaking 7

摘要

The mouse monoclonal antibody marketed as anti-adenomatous polyposis coli clone CC1, often referred to as CC1, is the antibody most commonly used to specifically label mature oligodendrocytes without labeling myelin. Previous studies have shown that despite being raised against adenomatous polyposis coli, this antibody binds another unknown antigen. We show that the CC1 antibody binds Quaking 7, an RNAbinding protein that is highly up-regulated in myelinating oligodendrocytes in the central nervous system.