Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine withou maintaining incrased density of nicoticic receptors in rodent brain

摘要

Chronic treatment with nicotine increases brain 42 nicotinic receptors, which may be related to nicotine addiction. When nicotine is replaced by varenicline, this receptor increase is maintained; in contrast, when nicotine is replaced by sazetidine-A the receptors return to baseline levels. The doses of drugs used here are anxiolytic and slow gain of body weight compared to saline controls.