Design and Fabrication of Grafting Poly(ethylene glycol) Monomethacrylate Onto Fe3O4 Nanoparticles via Surface-Initiated RAFT Polymerization to Resist Non-Specific Protein Adsorption

摘要

A new method for modification of Fe3O4 magnetite nanoparticles (MNPs) with poly(poly(ethylene glycol) monomethacrylate) (pPEGMA) has been developed by utilizing surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. The chemical composition of the functionalized MNPs was determined by FT-IR, XPS, EDS, TEM, TGA and SQUID analysis. The analytical results indicated a strong interaction between pPEGMA and MNPs owing to the covalent bonding and the superparamagnetic property of the synthesized nanoparticles. After surface modification of Fe3O4 nanoparticles with the pPEGMA flexible chains, non-specific adsorption of proteins on the surface of uncoated and functionalized MNPs was evaluated.