The influences of poly(lactic-co-glycolic acid) (PLGA) coating on the biodegradability, bioactivity, and biocompatibility of calcium silicate bioceramics

摘要

Calcium silicate (CaSiO _3) bioceramics and polyesters have complementary qualities as potential bone substituted materials. In this study, sintered CaSiO _3 bioceramics were prepared and coated with poly(lactic-co- glycolic acid) (PLGA), and the influences of the PLGA coating on the degradation, hydrophilicity, bioactivity, and biocompatibility of CaSiO _3 ceramics were investigated. The results showed that the degradation rate was reduced, while hydrophilicity was decreased with the increase of the polymer coating. In addition, the polymer coating resulted in a decrease of the alkaline pH value during the degradation of the ceramics, which indicated an increase of the cell biocompatibility, confirmed by the attachment and proliferation of rMSCs on the surface of the polymercoated ceramics. Furthermore, the apatite-forming ability of the PLGA-coated CaSiO _3 bioceramics was maintained. This study suggested that the coating with PLGA might be a useful method to improve the integrative properties of CaSiO _3 bioceramics for applications in bone regeneration and bone tissue engineering.