首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Study of the slope of the linear relationship between retention and mobile phase composition (Snyder-Soczewinski model) in normal phase liquid chromatography with bonded and charge-transfer phases
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Study of the slope of the linear relationship between retention and mobile phase composition (Snyder-Soczewinski model) in normal phase liquid chromatography with bonded and charge-transfer phases

机译:正键液相和电荷转移相液相色谱中保留度与流动相组成(Snyder-Soczewinski模型)之间线性关系的斜率研究

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The Snyder model and the Soczewinski model are compared on classic NPLC bonded phases using literature data, and on the charge transfer 2, 4-dinitroanilinopropyl (DNAP) column using experimentally collected data. Overall, the Snyder model slightly better predicts the n-slope than the Soczewinski model. However, both models give comparable uncertainty in predicting n-slope for a given compound. The number of aromatic double bonds was the most suitable descriptor for estimating the relative n-slope of PAHs, as it correlated with behavior better than the number of aromatic rings and is simpler to calculate than the solute adsorption area. On the DNAP phase, a modified Soczewinski model is suggested to allow for the significant contribution of the aromatic rings to the n-slope. For classic NPLC bonded phases and DNAP columns, the contribution of polar group to the n-slope parallels the adsorption energy of each polar group. (C) 2016 Elsevier B.V. All rights reserved.
机译:使用文献数据,在经典的NPLC键合相上比较Snyder模型和Soczewinski模型,并使用实验收集的数据在电荷转移2、4-二硝基苯胺基丙基(DNAP)色谱柱上进行比较。总体而言,与Soczewinski模型相比,Snyder模型对n斜率的预测稍好。但是,两种模型在预测给定化合物的n斜率时都具有可比的不确定性。芳香族双键的数目是估计PAHs相对n斜率的最合适的描述子,因为它与行为的相关性比芳香族环数更好,并且比溶质吸附面积更容易计算。在DNAP阶段,建议使用改良的Soczewinski模型,以使芳环对n斜率的贡献显着。对于经典的NPLC键合相和DNAP色谱柱,极性基团对n斜率的贡献与每个极性基团的吸附能平行。 (C)2016 Elsevier B.V.保留所有权利。

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