Speedy standing wave design of size-exclusion simulated moving bed: Solvent consumption and sorbent productivity related to material properties and design parameters

摘要

Size-exclusion simulated moving beds (SEC-SMB) have been used for large-scale separations of linear alkanes from branched alkanes. While SEC-SMBs are orders of magnitude more efficient than batch chromatography, they are not widely used. One key barrier is the complexity in design and optimization. A four-zone SEC-SMB for a binary separation has seven material properties and 14 design parameters (two yields, five operating parameters, and seven equipment parameters). Previous optimization studies using numerical methods do not guarantee global optima or explicitly express solvent consumption (D/F) or sorbent productivity (P-R) as functions of the material properties and design parameters.