Facile method for synthesis of hollow porous magnetic microspheres with controllable structure

摘要

Hollow porous magnetic microspheres with strong magnetization and controllable structure were prepared via a facile electrostatic self-assembly of the positively charged Fe _3O _4 nanoparticles onto the surface of the negatively charged poly(N,N'-methylenebisacrylamide-co-methacrylic acid) (P(MBAAm-co-MAA)) microspheres with subsequent removal of the polymer core through calcination at high temperature. The shell thickness was facilely tuned through the ratio between Fe _3O _4 and polymer, and the void space was conveniently changed through the size of polymer microspheres. The hollow magnetic microspheres possessed high saturation magnetization value (51.38emu/g) and porous structure with high specific surface area (108.04m ~2/g). Based on these properties, the drug loading and release behaviors were investigated, which indicated that the hollow magnetic microspheres exhibited a controlled release process.