Overlooked areas need attention for sound evaluation of DNA strand inheritance patterns in Drosophila male germline stem cells

摘要

In the 2011 report 'Drosophila male germline stem cells do not asymmetrically segregate chromosome strands' by Yadlapalli, Cheng, and Yamashita (J. Cell Science 124, 933-939) the authors report results from their investigation of DNA-strand inheritance in the well-described germinal stem cells (GSCs) that renew sperm in newly hatched Drosophila melanogaster males. They conclude that their findings do not support the hypothesis of non-random segregation of sister chromatids in these cells, unlike reports of several examples in mammalian cells (Lark, 1969; Merok et al., 2002; Rambhatla et al., 2005; Pine et al., 2010; Hari et al., 2011), and including adult tissue stem cells (Potten et al., 2002; Karpowicz et al., 2005; Smith, 2005; Capuco, 2007; Conboy et al.,2007).