Controllable synthesis of bifunctional NaYF_4:Yb~(3+)/Ho~(3+)@SiO_2/Au nanoparticles with upconversion luminescence and high X-ray attenuation

摘要

A novel type of bifunctional water-soluble NaYF_4:Yb~(3+)/Ho~(3+)@SiO_2/Au nanocomposite is fabricated by a facile layer-by-layer technology in which the mercapto-silica shell is used as the functional layer coating on the central NaYF_4:Yb~(3+)/Ho~(3+) nanocrystals. Then by adjusting the mole ratio of the Au nanoparticles to the NaYF_4:Yb~(3+)/Ho~(3+)@SiO_2 nanoparticles, control of the gold loading on the upconversion nanocrystal surface is achieved. The fabricated nanocomposites inherit the excellent physical and chemical properties from their building blocks, simultaneously exhibiting upconversion luminescence and high X-ray attenuation and as well are easily modified with various molecules. These properties render the synthesized NaYF_4:Yb~(3+)/Ho~(3+)@SiO_2/Au nanocomposite not only useful as a multimodality contrast agent to increase the efficiency of molecular imaging but also has the potential of in situ curing of diseases.