Synthesis of hyperbranched polycarbosilane modified with cyclodextrin derivatives and its application in coated capillary electrophoresis columns

摘要

A series of hyperbranched polycarbosilanes were synthesized and coated on the inner surface of fused-silica capillaries by chemical bonding. The end groups of the hyperbranched polycarbosilanes were modified with β-cyclodextrin derivatives. The chiral isomers of ofloxacin and chlorpheniramine were separated by this new type of chiral capillary electrophoresis column and high-column efficiency was achieved. The results showed that ofloxacin was completely separated at pH 3.0; the separation resolution was 2.32, and theoretical plates were greater than 4.5 × 10~4 plates m~(-1).