Two new types of copolymer membranes controlling clonidine zero-order release

摘要

Two new types of membranes were synthesized by UV curing in our laboratory. The first type of membrane was made of three monomers: 2-hydroxy-3-phenoxypropylacrylate(A), 4-hydroxybutyl acrylate(B), and 2-methyl-2-nitropropyl methacrylate(C1). The second type of membrane was made of the same monomers A and B, and 2-butoxyethyl methacrylate(C2). Permeation properties of clonidine releasing through two new types of copolymer membranes were studied. The effects of the ratios of monomers, the thicknesses of membranes, and the concentration of clonidine on the permeation rates were studied. It was found that both copolymer membranes could con-trol clonidine zero-order release. The permeation rates of the first optimized membrane were linearly dependent on the square root of the drug concentration. The permeation rates of the second optimized membrane had no significant difference when the concentration of clonidine varied in the range of 3.0-5.0 mg mL(-1). Furthermore, both optimized membranes were characterized by FTIR, DSC, and SEM. (c) 2007 Wiley Periodicals, Inc.