Effects of Hydrophilic and Lipophilic β-Sitosterol Derivatives on Cholesterol Absorption and Plasma Cholesterol Levels in Rats

摘要

The effects of two phytosterol derivatives of β-sitosterol, a lipophilic derivative (LPSS) and a hydrophilic derivative (HPSS), on cholesterol uptake and blood lipoprotein levels in rats were compared with those of β-sitosterol. LPSS and HPSS have solubilities of up to 0.05 g/mL in edible oil and 0.15 g/mL in water at 25 °C, respectively. The intragastric administration of either 30 or 50 mg of phytosterols with 10 mg of [4-~(14)C]-cholesterol per kg of body weight once a day for 3 consecutive days reduced cholesterol uptake by approximately 30% compared to controls that received cholesterol alone. Feeding a cholesterol-enriched diet containing 1% or 3% β-sitosterol, LPSS, or HPSS for 2 and 4 weeks resulted in lowered levels of total blood cholesterol and reduced the atherogenic index in all groups. These results indicate that LPSS and HPSS have comparable effects to β-sitosterol in lowering blood cholesterol levels but they differ from β-sitosterol in having a solubility advantage.