Levels of Bisphenol A in Canned Liquid Infant Formula Products in Canada and Dietary Intake Estimates

摘要

A sensitive,efficient,and reproducible method,based on solid phase extraction and derivatization with acetic anhydride followed by gas chromatography-mass spectrometry in selected-ion monitoring mode,was developed for the determination of bisphenol A(BPA)in liquid infant formula.The method quantification limit was 0.5 ng g~(-1).Extraction recoveries were 85-94% over the concentration range of 2.5-20 ng g~(-1).Good reproducibility of the method was observed at levels of 0.54 and 10.4 ng g~(-1)with relative standard deviations of 5.0 and 2.8%,respectively.The method was used to analyze samples of 21 canned liquid infant formula products for BPA.BPA was detected in all samples at levels ranging from as low as 2.27 ng g~(-1)to as high as 10.2 ng g~(-1).The probable daily intakes of BPA due to consumption of canned liquid infant formula were estimated for infants from premature to 12-18 months of age.The maximum probable daily intake of BPA was 1.35 mu g kg~(-1)of body weight day~(-1)for 0-1-month-old infants with the maximum formula intake,which is below the provisional tolerable daily intake for BPA established by Health Canada,25 mu g kg~(-1)of body weight day~(-1).