Is anti-TNF therapy safer than previously thought?

摘要

The inability of individual RCTs to address the safety of rare or long-term outcomes led to the establishment of European drug registers at the launch of anti-TNF therapy, along with other international studies. An analysis from the German biologies register reinforced the meta-analysis results by reporting a 2-fold increased risk of serious infection.7 However, subsequent studies reported risks ranging from no increased risk to a greater than 4-fold increased risk.