Organelle Biogenesis: En BLOC Exchange for RAB32 and RAB38

摘要

Prominent subtypes of the genetic disorder Hermansky–Pudlak syndrome result from defects in a mysterious protein complex, BLOC-3. New work identifies BLOC-3 as a guanine nucleotide exchange factor for two RAB GTPases previously implicated in lysosome-related organelle biogenesis.