Paracetamol use linked with cardiovascular risk

摘要

Researchers have discovered a consistent dose-response relationship between paracetamol use and risk of mortality or cardiovascular, gastrointestinal or renal adverse events. The team, led by Philip Conaghan from the Leeds Institute of Rheumatic and Musculoskeletal Medicine, says that the risks associated with taking the standard adult dose of paracetamol for pain relief are similar to those commonly associated with non-steroidal anti-inflammatory drugs. The finding "suggests a considerable degree of paracetamol toxicity especially at the upper end of standard analgesic doses".