Vitamin E may increase prostate cancer risk

摘要

DIETARY supplementation with vitamin E may increase prostate cancer risk, according to research published in JAMA (2011;306:1549). Analysis of the data at an earlier stage in the same trial found no significant increase in prostate cancer risk with vitamin E supplements (PJ, 1 November 2008, p495).In the latest analysis, the risk of prostate cancer at seven years of median follow up was 17 per cent higher among men randomised to vitamin E compared with placebo (hazard ratio 1.17, 99 per cent confidence interval 1.004-1.36: P=0.008), a difference which started to appear approximately three years after randomisation.