Convergent sequence evolution between echolocating bats and dolphins

摘要

In Drosophila, InsP(3) appears not to be involved, and recent studies have implicated lipid products of PLC activity, e.g., diacylglycerol, its metabolites, or the reduction in PIP2. The fact that hydrolysis of the phosphodiester bond in PIP2 by PLC also releases a proton is seldom recognized and has neither been measured in vivo nor implicated previously in a signaling context.Results: Following depletion Of PIP2 and other phosphoinositides by a variety of experimental manipulations, the light-sensitive channels in Drosophila photoreceptors become remarkably sensitive to rapid and reversible activation by the lipophilic protonophore 2-4 dinitrophenol in a pH-dependent manner.