Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

Fulcher Jordan; OConnell Rachel; Voysey Merryn; Emberson Jonathan; Blackwell Lisa; Mihaylova Borislava; Simes John; Collins Rory; Kirby Adrienne; Colhoun Helen; Braunwald Eugene; La Rosa John; Tonkin Andrew; Davis Barry; Sleight Peter; Franzosi Maria Grazia; Baigent Colin; Keech Anthony; de Lemos J.; Blazing M.; Downs J. R.; Gotto A.; Clearfield M.; Gordon D.; Koren M.; Dahloef B.; Poulter N.; Sever P.; Knopp R. H.; Fellstroem B.; Holdaas H.; Jardine A.; Schmieder R.; Zannad F.; Goldbourt U.; Kaplinsky E.; Colhoun H. M.; Betteridge D. J.; Durrington P. N.; Hitman G. A.; Fuller J.; Neil A.; Wanner C.; Krane V.; Sacks F.; Moye L.; Pfeffer M.; Hawkins C. M.; Wedel H.; Wikstrand J.; Barter P.; Tavazzi L.; Maggioni A.; Marchioli R.; Tognoni G.; Bloomfield H.; Robins S.; Pedersen T. R.; Ridker P. M.; Holman R.; Meade T.; MacMahon S.; Marschner I.; Shaw J.; Serruys P. W.; Nakamura H.; Knatterud G.; Furberg C.; Byington R.; Murphy M.; Blauw G. J.; Packard C.; Kjekshus J.; Pedersen T.; Wilhelmsen L.; Cannon C.; Murphy S.; Armitage J.; Bowman L.; Parish S.; Peto R.; Landray M.; Rossouw J.; Probstfield J.; Shepherd J.; Cobbe S.; Macfarlane P.; Ford I.; Flather M.; Kastelein J.; Newman C.; Shear C.; Tobert J.; Varigos J.; White H.; Yusuf S.; Barnes E. H.; Keech A. C.; Kirby A.; Marschner I. C.; Blackwell L.; Emberson J.; Herrington W. G.; Holland L. E.; Mihaylova B.; Reith C.

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Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

机译：男女降低LDL疗法的疗效和安全性：对27项随机试验中17.4万名参与者的个人数据进行荟萃分析

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Background Whether statin therapy is as effective in women as in men is debated, especially for primary prevention. We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database to compare the effects of statin therapy between women and men.

机译：背景技术对于女性，他汀类药物治疗是否与男性一样有效，尤其是在一级预防方面，一直存在争议。我们在胆固醇治疗试验家（CTT）协作数据库中对他汀类药物试验进行了荟萃分析，以比较他汀类药物在男女之间的疗效。

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《The Lancet》 |2015年第9976期|共9页
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Fulcher Jordan; OConnell Rachel; Voysey Merryn; Emberson Jonathan; Blackwell Lisa; Mihaylova Borislava; Simes John; Collins Rory; Kirby Adrienne; Colhoun Helen; Braunwald Eugene; La Rosa John; Tonkin Andrew; Davis Barry; Sleight Peter; Franzosi Maria Grazia; Baigent Colin; Keech Anthony; de Lemos J.; Blazing M.; Downs J. R.; Gotto A.; Clearfield M.; Gordon D.; Koren M.; Dahloef B.; Poulter N.; Sever P.; Knopp R. H.; Fellstroem B.; Holdaas H.; Jardine A.; Schmieder R.; Zannad F.; Goldbourt U.; Kaplinsky E.; Colhoun H. M.; Betteridge D. J.; Durrington P. N.; Hitman G. A.; Fuller J.; Neil A.; Wanner C.; Krane V.; Sacks F.; Moye L.; Pfeffer M.; Hawkins C. M.; Wedel H.; Wikstrand J.; Barter P.; Tavazzi L.; Maggioni A.; Marchioli R.; Tognoni G.; Bloomfield H.; Robins S.; Pedersen T. R.; Ridker P. M.; Holman R.; Meade T.; MacMahon S.; Marschner I.; Shaw J.; Serruys P. W.; Nakamura H.; Knatterud G.; Furberg C.; Byington R.; Murphy M.; Blauw G. J.; Packard C.; Kjekshus J.; Pedersen T.; Wilhelmsen L.; Cannon C.; Murphy S.; Armitage J.; Bowman L.; Parish S.; Peto R.; Landray M.; Rossouw J.; Probstfield J.; Shepherd J.; Cobbe S.; Macfarlane P.; Ford I.; Flather M.; Kastelein J.; Newman C.; Shear C.; Tobert J.; Varigos J.; White H.; Yusuf S.; Barnes E. H.; Keech A. C.; Kirby A.; Marschner I. C.; Blackwell L.; Emberson J.; Herrington W. G.; Holland L. E.; Mihaylova B.; Reith C.;
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2. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials [J] . Fulcher Jordan, OConnell Rachel, Voysey Merryn, The Lancet . 2015,第9976期

机译：男女降低LDL疗法的疗效和安全性：对27项随机试验中17.4万名参与者的个人数据进行荟萃分析
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8. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials [O] . Cholesterol Treatment Trialists’ (CTT) Collaboration, Fulcher Jordan, OConnell Rachel, 2015

机译：降低LDL疗法在男性和女性中的疗效和安全性：对27项随机试验中来自174,000名参与者的个人数据进行荟萃分析

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

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