Polio vaccination in Pakistan

摘要

Transmission of wild poliovirus (WPV) types 1 and 3 continued in Pakistan in 2012 (Aug 4, p 491)-1 The per-dose vaccine efficacy of trivalent oral polio vaccine (OPV) against WPV-1 was estimated to be only 12-5%.1 Even 100% coverage with a realistic number of trivalent OPV doses cannot eliminate WPV-1 where vaccine efficacy is so low. O'Reilly and colleagues recommend bivalent OPV for supplementary immunisation activities in preference to monovalent OPV-1 for the added advantage of addressing WPV-3 but without losing the edge on WPV-1.