Mendelian randomisation, lipids, and cardiovascular disease

摘要

In The Lancet, Benjamin Voight and colleagues use mendelian randomisation analysis to investigate the relation between HDL cholesterol and coronary heart disease. High HDL cholesterol concentration is associated with reduced risk of coronary heart disease in observational studies, but whether the association is causal cannot be unequivocally ascertained from these studies alone, and whether raising of HDL cholesterol would be an effective means to reduce risk of coronary heart disease remains uncertain