Dissociating HDL cholesterol from cardiovascular risk.

摘要

Cardiovascular disease is the leading cause of death worldwide. Reducing concentrations of LDL cholesterol with statin therapy has resulted in reductions of 23% in cardiovascular risk for every 1.03 mmol/L (40 mg/dL) decrease in LDL cholesterol.1 However, despite a reduction in LDL cholesterol with high-dose statins to 1-6 mmol/L in patients with stable coronary heart disease, and to 2.0 mmol/L in those with acute coronary syndrome, the risk of cardiovascular disease remains substantial at 8.7% after 4.9 years of follow-up, and 22-4% after 24 months' follow-up, respectively. Low concentrations of HDL cholesterol might contribute to this residual cardiovascular risk.