HDL cholesterol and residual risk of first cardiovascular events.

摘要

Paul Ridker and colleagues, in their assessment of JUPITER trial data (July 31, p 333)/ report that HDL cholesterol concentrations are not predictive of vascular risk in patients treated with potent statin therapy who attain very low concentrations of LDL cholesterol. This observation could have important clinical consequences. However, it is somewhat surprising in the context of other published studies which report that low HDL cholesterol concentrations do predict cardiovascular events in statin-treated patients with coronary atherosclerosis, in particular when LDL cholesterol concentrations are less than 1.8 mmol/L