Reporting genetic association studies: the STREGA statement.

摘要

The completion of sequencing of the human genome created high hopes for the translational potential of knowledge from genetic association studies. The combination of advances in genomic and related technologies and methods of conventional epidemiology has produced one of the most dynamic fields of medical research. Genome-wide association studies have led to an unparalleled growth and improved accuracy in genetic information. At the same time, the complexity of the available data has increased substantially. However, advances in the application of this knowledge, such as determination of an individual's risk of disease or development of personalised therapies, might not become available as quickly as expected. The devil is in the detail. For instance, for the suggested relation between several genetic polymorphisms and occurrence of sepsis in human beings, systematic review in 2006 of the study reports showed that the information needed to assess the risk of bias was lacking