Amodiaquine, malaria, pregnancy: the old new drug.

摘要

In today's Lancet, Harry Tagbor and colleagues report on the efficacy, safety, andtolerability of amodiaquine, alone and combined with sulfadoxine-pyrimethamine, in the treatment of malaria in pregnant women in Ghana.In endemic countries, malaria during pregnancy has a major effect on pregnant women's health, birthweight, fetal loss, infant morbidity, and survival. Infections during pregnancy require prompt and effective treatment. Sulfadoxine-pyrimethamine alone is the most commonly used combination for both treatment and prevention of malaria in pregnancy in Africa, but resistance is increasing alarmingly/and the arsenal of alternative antimalarials for use in pregnancy is remarkably limited for a disease with such a high public-health impact.