Re: Age-related alterations in T-lymphocytes modulate key pathways in prostate tumorigenesis

摘要

Editorial Comment: This study reveals that secreted cytokines from GPAT-1T lymphocytes closely mimic the cytokine array profile observed in normal aged T lymphocytes. Treatment of normal, nontransformed or prostate cancer cells with serum derived from the GPAT-1 mice induced NF-KB transcriptional activity and nuclear localization. Aging and aging mimic GPAT-1 T lymphocytes secrete factors that, compared to young wild-type T lymphocytes, differentially induce NF-KB activation and promote cellular proliferation in prostate epithelial cells. These data suggest that the aging immune system is not a passive component to tumorigenesis, but may actively promote initiation and progression through induction of inflammatory pathways.