Cell cycle: deconstructing tension.Comments Comment on: Curr Biol. 2010 Aug 10;20(15):1396-401; PMID: 20619650, Comment on: Curr Biol. 2010 Aug 10;20(15):1402-7; PMID: 20619651

摘要

Prior to anaphase, sister chromatids must be attached to microtubules and under tension, a condition that satisfies the spindle checkpoint. Removal of sister chromatid cohesion is predicted to cause a fall in tension. Two studies shed light on how cells avoid re-activation of the spindle checkpoint when cohesion is lost