Re: The New England Research Institutes, Inc. (NERI) Nocturia advisory conference 2012: Focus on outcomes of therapy: Editorial comment

摘要

Editorial Comments Nocturia is a condition that has a multifactorial etiology and at a frequency of 2 times or greater is associated with detrimental effects on sleep quality, mood, depression, overall quality of life and perhaps even mortality. This article is a summation of a conference focused on updating recent outcome studies related to this area. The article provides a useful review. Key conclusions include the following: 1) questionnaires such as the Prostate Symptom Score do not adequately estimate the frequency or prevalence of nocturia—this is best done by the use of frequency-volume charts; 2) the observed detrimental effects of nocturia follow a dose response pattern; 3) there is a causative relationship between sleep disorder breathing (primarily obstructive sleep apnea) and nocturia, and excellent results are generally achieved in such cases when sleep apnea is successfully managed; 4) the evidence base for determinations of efficacy of various treatments is weak; 5) multicomponent behavioral interventions may be attractive but the limited evidence base limits definite conclusions regarding this; 6) antimuscarinics as stand-alone therapy rarely offer clinically significant benefit over placebo, although they may be useful as part of multi-modality therapy in patients with severe nocturnal urgency