Our point was to evaluate the relationship between prostate size and high grade cancer, specifically to address the claim that a small prostate is a surrogate marker for aggressive disease.In men with palpable disease there was no such association on multivariate logistic regression. The concern about model overfit is well taken. However, overfit models typically result in falsely significant p values and not the other way around. The concern about statistical power is also valid. To address each concern we reran analysis with a more parsimonious model that included only 3 predictors (prostate size, PSA and age). It yielded results similar to those of the full model.
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