Patients with plasma cell neoplasia typically present with diffuse marrow involvement, multiple osseous plasmacytomas or both and 1 or more extramedullary plasmacytomas, a condition called multiple myeloma. Infrequently a patient presents with a single osseous or extramedullary (solitary) plasmacytoma. About 80% to 90% of extramedullary plasmacytomas develop in the head and neck area, especially in the aerodigestive tract. Less commonly they arise in diverse sites anywhere in the body, including the bladder, testis and epididymis.
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