Stereoselective alpha-Hydroxylation of Amides Using Oppolzer's Sultam as Chiral Auxiliary

摘要

An Oppolzer's sultam-based highly stereo selective alpha-hydroxylation of amides was developed to deliver the desired products in good yield and excellent diastereoselectivity (>20/1). The generally crystalline products and the recyclability of the chiral auxiliary illustrate the practicability and scalability of the current approach.