Bi(OTf)(3)-Catalyzed Multicomponent alpha-Amidoalkylation Reactions

摘要

A bismuth(III) triflate catalyzed three-component synthesis of alpha-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.