Copper/Silver-Mediated Cascade Reactions for the Construction of 2?Sulfonylbenzo[b]furans from trans-2-Hydroxycinnamic Acids and Sodium Sulfinates

摘要

Efficient construction of 2-sulfonylbenzo[b]furans is achieved from readily available trans-2-hydroxycinnamic acids and sodium sulfinates mediated by the CuCl_2·2H_2O/AgTFA system under mild conditions. This unprecedented synthetic protocol provides expedient access to a series of products in one step via a protodecarboxylation/C?S bond formation/C?O bond formation cascade.